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Tim Blixseth is an American genuine estate mogul and billionaire businessman.
Donald Bren, according to is the wealthiest actual estate tycoon on the planet with a $12 billion net worth. President and CEO of Mori Trust, his family?s organization owns genuine estate and hotels in Tokyo and all over Japan.
Minoru Mori is also a famous Japanese genuine estate tycoon and billionaire.
World?s Richest Genuine Estate Moguls
Very a couple of are locating that there?s an abundance of actual estate chance in emerging nations about the world which has developed a robust demand for actual estate finance overseas.
For these thinking about joining the jet-to-let actual estate investment set correct here are the 3 primary selections offered when it comes to raising real estate finance, loans or mortgages to get property abroad.
The negative side of this alternative to raise genuine estate finance to invest in overseas property is that the purchaser?s significant residence will be the security against the loan and naturally this introduces an element of danger.
2) The second choice accessible to buyers hunting for actual estate finance overseas is getting a mortgage locally in the nation in which they want to decide to decide to buy. Everybody hoping to raise finance to obtain real estate overseas will have to have to seek professional economic tips.
Source: http://www.koguryo.org/actual-estate-finance-overseas/
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The pre-eminent communications systems event for the working world.
International Wireless Communications Expo (IWCE)
- February 20-24, 2012 ? ? - Las Vegas Convention Center
- Courses Feb 20-21 ? - Expo Feb. 22-234 ? - Over 330 Exhibitors
College of Technology: 25 courses, including: ? - Land Mobile Radio for the IT Professional ? - Spectrum Opportunities in a Narrowbanded Environment ? - Wireless Surveillance Ecosystem ? - Software Applications over IP ? - LTE Voice Options and Operations ? - NIMS/ICS 400 ? - 4G, LTE and Broadband Overview ? - TETRA for North America ? - Mobile Data and Multimedia Fundamentals ? - Smart Grid 101 ? and more!
55 Sessions: ? - Optimizing the 4G Cloud for Interoperable Communications ? - IP in an LMR World ? - Future Planning for Legacy Networks ? - Interference Analysis: Theory and Practice ? - Case Studies on Next-Gen Communications in Airports ? - Deploying LTE and Broadband Wireless in a Rural Setting ? - Analog or Digital? How to Make the Decision ? and more!
For information and to register, visit www.iwceexpo.com
Source: http://www.e-grid.net/BayAreaTech/?p=2607
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Tiger Woods fired a six-under par 66 Saturday. After three rounds, Tiger Woods is now tied with Britain's Robert Rock for the lead of the Abu Dhabi Championship.
?A host of pinpoint golf shots and a deadly touch with the putter helped Tiger Woods to move within sight of his first victory in a full-field event for more than two years at the Abu Dhabi Championship on Saturday.
Skip to next paragraphThe former world No. 1 was kitted out in grey shirt and trousers but there was nothing grey about his game as he fired a sizzling six-under-par 66 to join Britain's Robert Rock (66) in a tie for the lead on 11-under 205.
Swede Peter Hanson returned the best round of the week, a 64, giving him a share of third place on 207 with world number three Rory McIlroy (68), fellow Briton Paul Lawrie (68) and Italian Francesco Molinari (66).
IN PICTURES: Tiger Woods through the years
There was a logjam at the top, with the leading 14 players separated by four shots.
?Woods, who ended a two-year title drought by winning last month's Chevron World Challenge limited-field event in California, refused to get carried away with his six-birdie display at the European Tour event.
"I was just kind of consistent today," the American said in understated fashion. "I didn't do a whole lot wrong and didn't do a whole lot right.
"I played methodically, just plotted my way round the golf course and the birdies just piled up."
With hardly any wind on another hot day at the Abu Dhabi Golf Club, scoring improved and at one point there were eight players tied for the lead.
Woods went to the top of the leaderboard on his own by rolling in a 15-foot birdie putt at the 14th.
He kept his errors to a minimum throughout, a feature of his performances this week, and has now carded just two bogeys in 54 holes.
His distance control with his woods and irons evoked memories of the record 623 weeks he spent as world number one and his putting stroke was pure and positive.
The 25th-ranked Woods gave an ironic 'great shot' cry when he played a rare poor tee shot 60 feet right of the pin at the 15th but he managed to get down in two for his par three.
GLORIOUS APPROACH
The 36-year-old then finished his round with a flourish, shaping a glorious five-wood approach from left to right at the par-five 18th and safely two-putting from 60 feet to claim his sixth birdie of a flawless round.
With a plethora of players waiting to pounce on any slip, Woods knows he will have to be aggressive in Sunday's final round.
"There are so many guys up there I'm going to have to post a good number," he said. "It's not like I can just go round and shoot par."
Rock, who won his first tour event at last year's Italian Open, crammed five birdies into the last nine holes and the bearded Englishman was thrilled at the prospect of playing alongside Woods on the last day.
"I can't wait," said the 34-year-old, who was an unknown club professional nine years ago. "I might not get too many opportunities to do that."
Asked if he had ever imagined playing alongside one of golf's greatest players, he replied: "No, not in a million years. Not long ago I was working in a golf shop, selling Mars bars and watching him win majors on television.
"Tomorrow is going to be pretty cool. I'm just going to enjoy the opportunity."
McIlroy, who incurred a two-shot penalty for using his hand to brush away sand on the fringe of the ninth green on Friday, was involved in a lengthy rules discussion for the second day running.
The U.S. Open champion hit a wayward drive way right into the desert scrub at the 18th and had to ask the referee if he was allowed to aim further right for his next shot without going out of bounds.
McIlroy took an eventful route up the last hole but a par five kept him in touch with the leaders.
World number two Lee Westwood will look to make a last-day charge after shooting a 68 for 212 but top-ranked Luke Donald is out of title contention after sliding to a 73 for 216.
(Editing by Clare Fallon. To comment on this story email sportsfeedback@thomsonreuters.com)
IN PICTURES: Tiger Woods through the years
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DETROIT ? The Detroit Symphony Orchestra has launched a webcast player that will allow music lovers to enjoy an upcoming performance of Mozart's Horn Concerto No. 4 and other concerts online for free in the comfort of their homes.
People in about 40 countries are expected to view Saturday's high-definition "Live from Orchestra Hall" webcast, and the orchestra expects its webcast series to surpass 30,000 views with this weekend's episode.
The orchestra said the webcast player will make online viewers feel as if they are sitting in Detroit's Orchestra Hall.
The Symphony said it is the only U.S. orchestra to offer a free series of webcasts, which are made possible through contributions from the John S. and James L. Knight Foundation and the Ford Motor Co. Fund.
The new viewing environment mimics the interior of Orchestra Hall, giving audiences across the world the same view as local music lovers.
The webcast player also features dimming controls so that viewers at home can control their own version of the house lights.
Audience members now will be able to view a full schedule of upcoming webcasts and add them their online calendars. Viewers also can tweet directly from the webcast player page and follow the feed in the same browser window, allowing audience members to interact with fellow concertgoers while watching the concert at the same time.
The piece being played at any moment will be highlighted on a live repertoire tracker, and live program notes will post below the viewing window with trivia about the piece and the artists.
The "Live From Orchestra Hall" series is one of three new digital initiatives the DSO is introducing this season. Also new to the orchestra's digital repertoire are DSO To Go, a free mobile app, and the Symphony's first downloadable, digital album produced in-house.
___
Online:
Detroit Symphony Orchestra: http://www.dso.org/
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This citizen journalism image provide by the Local Coordination Committees in Syria and released early Friday Jan. 27, 2012, purports to show a Syrian man, right, mourning over the dead body of his son, who was shot by the Syrian forces, in Idlib province, Syria, on Thursday Jan. 26, 2012. A "terrifying massacre" in the restive Syrian city of Homs has killed more than 30 people, including small children, in a barrage of mortar fire and attacks by armed forces loyal to President Bashar Assad, activists said Friday. (AP Photo/Local Coordination Committees in Syria) EDITORIAL USE ONLY, NO SALES, THE ASSOCIATED PRESS IS UNABLE TO INDEPENDENTLY VERIFY THE AUTHENTICITY, CONTENT, LOCATION OR DATE OF THIS HANDOUT PHOTO
This citizen journalism image provide by the Local Coordination Committees in Syria and released early Friday Jan. 27, 2012, purports to show a Syrian man, right, mourning over the dead body of his son, who was shot by the Syrian forces, in Idlib province, Syria, on Thursday Jan. 26, 2012. A "terrifying massacre" in the restive Syrian city of Homs has killed more than 30 people, including small children, in a barrage of mortar fire and attacks by armed forces loyal to President Bashar Assad, activists said Friday. (AP Photo/Local Coordination Committees in Syria) EDITORIAL USE ONLY, NO SALES, THE ASSOCIATED PRESS IS UNABLE TO INDEPENDENTLY VERIFY THE AUTHENTICITY, CONTENT, LOCATION OR DATE OF THIS HANDOUT PHOTO
This citizen journalism image provided by the Local Coordination Committees in Syria and released on Friday Jan. 27, 2012, purports to show the bodies of five Syrian children wrapped in plastic bags, with signs in Arabic identifying them by name. Activists say the children were killed in a shelling attack by Syrian forces, in the Karm el-Zaytoun neighborhood of Homs, Syria, on Thursday Jan. 26, 2012 A "terrifying massacre" in the restive Syrian city of Homs has killed more than 30 people, including small children, in a barrage of mortar fire and attacks by armed forces loyal to President Bashar Assad, activists said Friday. (AP Photo/Local Coordination Committees in Syria) THE ASSOCIATED PRESS IS UNABLE TO INDEPENDENTLY VERIFY THE AUTHENTICITY, CONTENT, LOCATION OR DATE OF THIS HANDOUT PHOTO EDITORIAL USE ONLY
An anti-Syrian regime protester, gestures during a demonstration against Syrian President Bashar Assad, at Khalidya area in Homs province, central Syria, on Thursday, Jan. 26, 2012. Syrian troops stormed a flashpoint suburb of Damascus on Thursday, rounding people up in house-to-house raids and clashing with army defectors, activists said, as the 10-month-old uprising inches ever closer to the capital. (AP Photo)
Syrian army defectors stand guard on a rooftop to secure an anti-Syrian regime protest in the Deir Baghlaba area in Homs province, central Syria, on Friday, Jan. 27, 2012. Armed forces loyal to President Bashar Assad barraged residential buildings with mortars and machine-gun fire, killing at least 30 people, including a family of women and children during a day of sectarian killings and kidnappings in the besieged Syrian city of Homs, activists said Friday. (AP Photo)
Syrian army defectors secure a street near an anti-Syrian regime protest in the Deir Baghlaba area of Homs province, central Syria, on Friday, Jan. 27, 2012. Armed forces loyal to President Bashar Assad barraged residential buildings with mortars and machine-gun fire, killing at least 30 people, including a family of women and children during a day of sectarian killings and kidnappings in the besieged Syrian city of Homs, activists said Friday. (AP Photo)
BEIRUT (AP) ? Two days of bloody turmoil in Syria killed at least 74 people, including small children, as forces loyal to President Bashar Assad shelled residential buildings and fired on crowds in a dramatic escalation of violence, activists said Friday.
Video posted online showed the bodies of five small children, five women and a man, all bloodied and piled on beds in what appeared to be an apartment after a building was hit in the city of Homs. A narrator said an entire family had been "slaughtered."
Much of the violence was focused in Homs, where heavy gunfire hammered the city Friday in a second day of chaos. A day earlier, the city saw a flare-up of sectarian kidnappings and killings between its Sunni and Alawite communities, and pro-regime forces blasted residential buildings with mortars and gunfire, according to activists.
At least 384 children have been killed, as of Jan. 7, in the crackdown on Syria's uprising since it began nearly 11 months ago, the U.N. children's agency UNICEF said Friday. The count, based on reports from human rights groups, included children under age 18.
Most of the deaths took place in Homs and most of the victims were boys, UNICEF said. It said 380 children have been detained, including some under age 14. The United Nations estimates that more than 5,400 people have died in the turmoil.
The U.N. Security Council met in a closed-door session to discuss the crisis, which diplomats said was a step toward a possible U.N. resolution against the Damascus regime.
However, any resolution faces strong opposition from China and Russia, and both nations have veto power. Russian Deputy Foreign Minister Gennady Gatilov said Friday that Moscow will oppose any resolution because it does not exclude the possibility of outside military interference.
The Syrian uprising, which began last March with mostly peaceful protests, has become increasingly violent in recent months as army defectors clash with government forces and some protesters take up arms to protect themselves. The violence has inflamed the sectarian divide in the country, where members of Assad's Alawite sect dominate the regime despite a Sunni Muslim majority.
Activists said at least 35 people were killed in Homs on Thursday and another 39 people were killed across the country Friday.
The video posted Friday by activists showed the bodies of five young children, their faces bloodied, wrapped in orange plastic bags. It said the children were believed to be from two families, the Akras and the Bahadours. Brown cardboard placards with the children's names written in Arabic were placed on their chests, identifying them: Thanaa, Ali, Najm, Abdul-Ghani and Sidra.
The video could not be independently verified.
Hilal Khashan, a political science professor at the American University of Beirut, said the spike in violence was linked to increasing pressure from the international community, the Arab League and the United Nations.
"The regime is trying to finish the matter through military means as soon as possible," and for that reason the level of violence increased," he said.
On Tuesday, Syrian Foreign Minister Walid al-Moallem insisted that Damascus will continue its crackdown and said Syria would not accept any international interference in its affairs.
Assad's regime claims terrorists acting out a foreign conspiracy by the U.S., Israel and Gulf Arab countries are behind the uprising, not protesters seeking change.
The head of Arab League observers in Syria said in a statement that violence in the country has spiked over the past few days. Sudanese Gen. Mohammed Ahmed al-Dabi said the cities of Homs, Hama and Idlib have all witnessed a "very high escalation" in violence since Tuesday.
A "fierce military campaign" was also under way in the Hamadiyeh district of Hama since the early hours of Friday, according to the British-based Syrian Observatory for Human Rights and other activists. They said the sound of heavy machine-gun fire and loud explosions reverberated across the area.
Some activists reported seeing uncollected bodies in the streets of Hama.
Elsewhere, a car bomb exploded Friday at a checkpoint outside the northern city of Idlib, the Observatory said, citing witnesses. The number of casualties was not immediately clear.
Details of the wave of killings in Homs emerged Friday from an array of residents and activists
"There has been a terrifying massacre," Rami Abdul-Rahman, director of the Syrian Observatory for Human Rights, told the AP on Friday. He called for an independent investigation.
Thursday started with a spate of sectarian kidnappings and killings between the city's population of Sunnis and Alawites, a Shiite sect to which Assad belongs as well as most of his security and military leadership, said Mohammad Saleh, a centrist opposition figure and resident of Homs.
There was also a string of attacks by gunmen on army checkpoints, Saleh said. Checkpoints are a frequent target of dissident troops who have joined the opposition.
The Observatory said at least 11 people, including eight children, died when a building came under heavy mortar and machine-gun fire in the city's Karm el-Zaytoun neighborhood. Some residents spoke of another massacre that took place when shabiha ? armed regime loyalists ? stormed the district, slaughtering residents in an apartment, including children.
"They are killing people because of their sect," said one Sunni resident of Karm el-Zaytoun, speaking on condition of anonymity for fear of reprisal.
Thursday's death toll in Homs was at least 35, said the Observatory and the Local Coordination Committees, an umbrella group of activists. Both groups cite a network of activists on the ground in Syria for their death tolls.
The reports could not be independently confirmed. Syria tightly controls access to trouble spots and generally allows journalists to report only on escorted trips, which slows the flow of information.
Also Friday, Iran's official IRNA news agency said gunmen in Syria kidnapped 11 Iranian pilgrims traveling by road from Turkey to Damascus.
Iranian pilgrims routinely visit Syria ? Iran's closest ally in the Arab world ? to pay homage to Shiite holy shrines. Last month, seven Iranian engineers building a power plant in central Syria were kidnapped. They have not yet been released.
The Free Syrian Army, a group of army defectors fighting the regime, released a video on its Facebook page claiming responsibility for the kidnapping and saying the Iranians were taking part in the suppression of the Syrian people.
___
AP writer Elizabeth A. Kennedy contributed to this report from Beirut.
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By ROB HARRIS
AP Sports Writer
Associated Press Sports
updated 9:30 a.m. ET Jan. 26, 2012
LONDON (AP) -Predicting the outcome of football matches on Twitter could land players in trouble, as the English football authorities are wary they could be seen to be providing inside betting information.
Queens Park Rangers captain Joey Barton used Twitter on Thursday to claim that the English Football Association had warned him not to provide opinions about the outcome of matches.
The FA regulations warn players that they cannot bet on games in competitions in which their club is involved or "pass inside information on to someone else which they then use for betting."
On Sunday, Barton correctly predicted to more than 1.1 million followers ahead of Sunday's Premier League matches that Manchester City would beat Tottenham and Manchester United would win at Arsenal.
According to Barton, the comments raised alarm bells at FA headquarters, although the governing body declined to comment.
"Just received my weekly warning letter from FA headquarters, this time regarding me tweeting about predicting the weekend's Manchester double," Barton wrote Thursday on his verified Twitter account. "According to the FA, I am not allowed to give my opinion of possible results in case that is seen as insider information. These people are so out of touch with reality it's untrue.
"What difference does my opinion of the outcome of a match have on the result? None."
The FA rules warn players: "You should be aware that the passing of information would not just be by word of mouth - the rule applies equally to emails or social networking sites (e.g. Facebook, Twitter)."
But Barton believes the FA has not got "to grips with the change that's happening in the world around them," claiming that he has "probably" received 30 letters from the organization since he started tweeting in July 2010.
The midfielder first revealed in October that the FA had told him to moderate his online comments.
"The FA came to hush me down or make me not have an opinion," he said.
While using Twitter to transform his image since being jailed in 2008 for assault in a street fight, Barton has also used the platform to attack the hierarchy at former club Newcastle and criticize Neil Warnock after he was fired as QPR manager earlier this month.
---
Rob Harris can be reached at www.twitter.com/RobHarrisUK
? 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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More newsChristopher Pasatieri / Getty ImagesU.S. defender Tim Ream cancels his honeymoon in Tahiti and heads east after being contated by English Premier League club Bolton.
Hope Solo has an ailing leg, the result of some extra work she was putting in to get back into playing shape after "Dancing With the Stars."
Source: http://nbcsports.msnbc.com/id/46145514/ns/sports-soccer/
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WEDNESDAY, Jan. 25 (HealthDay News) -- U.S. military personnel and veterans are plagued by substance abuse, depression and suicide, three new studies indicate.
In one study, researchers surveyed nearly 600 veterans returning from war zone deployment in Iraq or Afghanistan, and found that they were at increased risk for mental health problems and alcohol and drug abuse.
Nearly 14 percent of the veterans screened positive for probable post-traumatic stress disorder (PTSD), 39 percent for probable alcohol abuse, and 3 percent for probable drug use. Men reported more alcohol and drug use than women, but there were no gender differences in PTSD or other mental health conditions.
Veterans returning from Iraq reported more depression or functioning problems and more alcohol and drug use than those returning from Afghanistan. Army and Marine veterans reported worse mental and physical health than Air Force or Navy veterans.
The studies were published online Jan. 25 in the American Journal of Public Health and are scheduled to appear in the March supplement print issue of the journal.
In the second study, researchers found that major depression and substance use disorders have increased among active duty combat-exposed veterans. The finding comes from an analysis of data from 678,382 active personnel serving between 2001 and 2006.
Those who were deployed to Iraq or Afghanistan were more likely to be diagnosed with major depression or substance abuse than non-deployed personnel. Army and Marine Corps personnel were more likely to be diagnosed with the conditions than Navy and Air Force personnel.
"Our study provided valuable insight for the mental health readiness of the U.S. armed services and implications for potential, continued support of ongoing operations and their post-deployment health care needs," the researchers wrote in a journal news release.
"Given the continuing U.S. military presence in Afghanistan and other parts of the world, and the increasing trend in major mental health conditions reported in the U.S. military, it would be important for the Department of Defense to assess whether the current system has adequate resources and manpower to handle the increasing number of active duty personnel who need mental health services," they concluded.
The third study found that suicide rates for all U.S. military services increased between 2005 and 2007, particularly for members of the regular Army and National Guard.
The analysis of data from 2,064,183 active duty personnel in 2005 and 1,981,810 active duty personnel in 2007 also showed that mental health diagnoses, mental health visits, prescriptions for selective serotonin reuptake inhibitor (SSRI) antidepressants and sleep medicines, reduction in rank, enlisted rank and separation or divorce were all associated with suicides.
Deployment to Iraq or Afghanistan were associated with an elevated risk of suicide among all services in 2007, and for the Army in 2005.
The increased risk of suicide associated with deployments in 2007 compared with 2005 may be due to the extended duration of war and increasing lengths of deployment for Army and Air Force personnel, the researchers suggested.
"Additional research needs to address the increasing rates of suicide in active duty personnel. This should include careful evaluation of suicide prevention programs and the possible increase in risk associated with SSRIs and other mental health drugs, as well as the possible impact of shorter deployments, age, mental health diagnoses and relationship problems," the researchers concluded.
More information
The American Psychiatric Association has more about military mental health.
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LONDON ? The European movie industry and beyond is coming to terms with the death of Greek director Theo Angelopoulos after the acclaimed filmmaker sustained severe injuries in a road accident Tuesday evening.
The web and wires all carried the news of the 76-year-old filmmaker?s death who was hit by a motorbike while shooting The Other Sea in the port of Piraeus outside the Greek capital Athens.
After being rushed to hospital, Angelopoulos later died.
Born in 1935, the filmmaker took a job at the French Cinematheque in Paris as a protege of Henri Langlois after an early tryout in law in Athens.
He returned to his native Greece and shot his first feature film, Reconstruction (1970) in black and white. It occupies a place in Greek cinema history for its realistic approach.
Angelopoulos first came to international attention with his epic The Travelling Players (1975) which unspooled in the Festival de Cannes? Directors' Fortnight sidebar.
References to Greek mythology and history became a consistant factor in his filmmaking.
"He was a great European filmmaker, a true public intellectual, one of that generation who also loved to sit, eat, drink and talk politics," said Berlin Film Festival director Dieter Kosslick. "He was entirely his own man. He believed completely in an unique, European cinema and was a big fighter for independent cinema in general and European film in particular."
Nods for his filmmaking endeavors include a Venice Golden Lion for The Beekeeper in 1986 and the European Film Academy Award for Landscape In The Mist (1988).
Festival de Cannes prizes include a best script nod with Tonino Guerra for Voyage To Cythera (1984) and a Palm d?Or for Eternity And A Day (1998).
He is survived by his wife and producer of most of his films, Phoebe, and three daughters.
Source: http://www.rottentomatoes.com/m/1924371/news/1924371/
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Brian Brown has been taking antiretroviral drugs for five years. If he stops, the human immunodeficiency virus, or HIV, in his body will multiply and eventually, he'll get really sick. "You have to take them with food," Brown said. "Even if you aren't really hungry." A 39-year-old licensed practical nurse, Brown has to remember to take his drugs daily. It's a routine familiar to people with all kinds of chronic diseases, including HIV and diabetes.
Brown got a break, though. In 2010, he was part of a study of a new kind of vaccine for HIV, called Vacc-4x, from a company called Bionor. He was able to stop taking his two drugs for almost two years. The vaccine didn't cure him, but it cut down the number of HIV viral particles in his body to nearly undetectable levels, and his immune system's virus-fighting cells, called T-cells, went up.
Vacc-4x is just one HIV treatment that illustrates a new approach to HIV vaccines that has gained increasing currency in the last few years. Most people think of vaccines as a preventative measure, and early efforts to control HIV were focused on that strategy. The problem is that even though some are promising, preventing infection doesn?t do any good for the 34 million people worldwide who are already infected. To stop the spread, the key might be a post-infection vaccine like those given for rabies.
HIV, however, is a tough nut to crack. It attacks the very cells that detect and kill invading pathogens. Even when it isn't actively replicating, it can live in tissues in the nervous system or the gut for years. This is one reason HIV takes so long to manifest, and why the immune system has a tough time recognizing it and destroying infected cells. [7 Devastating Infectious Diseases]
Currently, the best way to treat HIV is with antiretroviral therapy ? drugs that aim at keeping the levels of virus in a person's blood low. These drugs have extended life spans, allowing for normal lives and reducing the chances of transmitting the virus. However, the side effects can negatively affect health, bringing liver problems and nausea.
There is also the problem of sticking to the drug regimen. "Adherence is a challenging thing," said Frank Oldham, chief executive officer of the National Association of People With AIDS.
Enter: new HIV vaccines
There are several therapeutic vaccines in development. Approaching HIV in slightly different ways, all are designed to allow the body's immune system to at least fight the virus to a standstill, and perhaps even keep it at undetectable levels. Common to all treatments is giving the immune system some way to recognize HIV. The vaccines differ in the markers (called antigens) they use to flag HIV particles, and in how they are delivered to the body.
Vacc-4x trains a person's immune system to recognize and fight a key protein that HIV relies on, called gp24. It also stimulates the production of white blood cells, which normally are killed by the virus. Early results show patients' viral loads coming down by a factor of three.
Genetic Immunity, a U.S.-Hungarian company, is testing a vaccine called DermaVir. Rather than focusing on a single protein, DermaVir uses a tiny bit of HIV DNA (called plasmid DNA) to generate a set of 15 chemical markers that the body's T-cells can recognize. The idea is to maximize the number of ways the immune cells can "see" the virus. The vaccine is administered by rubbing the skin enough to irritate it. Cells called dendritic cells will pick up a nanoparticle containing the DNA and deliver it to the lymph nodes, where the infection-fighting T-cells are generated.
The vaccine has been tested on about 70 patients so far and showed a 70 percent reduction in viral load, according to Genetic Immunity?s president, Dr. Julianna Lisziewicz. Another set of trials on patients is currently under way. [AIDS: A 'Winnable' Public Health Battle?]
Another approach is being taken by Gaithersburg, Md.-based company VIRxSYS, which uses a genetically altered HIV virus to deliver the vaccine. The body doesn't recognize HIV easily, and thus won't mount an immune response to the very vehicle delivering the medicine, said Franck Lemiale, senior director of immunobiology at the company.
To make sure that the T-cells will "see" many strains of HIV, the VIRxSYS vaccine uses proteins called Gag, Pol and Rev, which tend to be the same in all of variations of the HIV virus.
The company said in July 2011 that a version of its vaccine tested in monkeys, called VRX1273, had not only brought the viral loads down to undetectable levels in body fluids, but in tissues as well. If that result can be duplicated in humans, it might mean that the vaccine is helping the body to eliminate the virus entirely.
Vaccine vectors
Other groups are trying different delivery modes, or vectors. Dr. Chil-Yong Kang, a virologist at the University of Western Ontario, heads up a lab whose preventative vaccine, after receiving FDA approval in December, will go into trials designed to determine the safety of the vaccine. Kang hopes his vaccine, which would ride into the body on another virus, will also enable the body to attack infected cells in the tissues where HIV likes to hide.
Perhaps the most high-tech vaccine under development is from Argos Therapeutics, called AGS-004. Monocytes, a type of white blood cell, are taken from the patient, and artificially induced to become immature dendritic cells. Those cells are then exposed to the RNA (a molecule similar to DNA) of HIV particles taken from the patient until they produce antigens, red flags of sorts, to alert the immune system of the virus. Re-introduced to the patient, they can then bring the antigens to the T-cells, which then find and kill HIV.
Of the vaccines, Vacc-4x, Argos and Dermavir are closest to being approved for general use, with Vacc-4x having just finished phase 2 trials for efficacy in humans and Argos and Dermavir in phase 2b. That means all are seen as safe to use, have been tested in small groups, and will next be tested in large populations (phase 3). The others are either still being tested in animals or in the safety phases of testing.
"Clearly this field is young enough that we don't have a product that we can say is the greatest," said Dr. David M. Asmuth, co-director of the Clinical Research Center at the University of California, Davis, Medical Center, which administered the Vacc-4x to HIV patient Brown. While the trials have shown promise, he is still cautious.
Asmuth notes the Vacc-4x trial Brown was in showed a reduction in viral load. But it is still unclear how long that would last once the patients were off ART.
He also noted that HIV-positive individuals have a "set point" ? a viral load that stabilizes after infection, and can remain stable for years. When people get sick, it is because the number of virus copies suddenly increases and the immune system is overwhelmed. The current crop of vaccines being tested may only change the set point to something lower. That is still a good thing, but it isn't a cure.
What would be ideal, Asmuth said, is a vaccine that reproduces what doctors see in people whose own bodies keep HIV under control for years, sometimes indefinitely. They are called "long-term non-progressors." Their viral loads should stay low and the CD4 count (a measure of immune health) should stay at 500-600, which is normal (a CD4 count less than 200 is often used as the diagnosis for AIDS). None of the vaccines being tested has shown they can do that ? yet.
Even so, Asmuth is optimistic. "Who would have guessed 30 years ago that we would have the degree of control over the virus that we have now?"
Oldham said the fact that such therapies are in trials at all is exciting. "This would be a monumental breakthrough," he said. "Antiretrovirals were the beginning. I think therapeutic vaccines would be the next step towards improving lives."
Brown meanwhile, said the Vacc-4x trial meant many of the small routines he built up over years won't be necessary anymore ? and small changes add up. "I didn't have to remember to take my pills," he said. "I could travel without having to think about bringing them."
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WASHINGTON (Reuters) ? President Barack Obama will host Italian Prime Minister Mario Monti in Washington on February 9 and will discuss efforts to tackle the debt crisis that has threatened Italy and the wider euro zone, the White House said on Monday.
"The two leaders will discuss the comprehensive steps the Italian government is taking to restore market confidence and reinvigorate growth through structural reforms, as well as the prospect of an expansion of Europe's financial firewall," the White House said in a statement.
(Reporting By Alister Bull; Editing by Will Dunham)
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By STUART CONDIE
AP Sports Writer
Associated Press Sports
updated 9:23 a.m. ET Jan. 23, 2012
LONDON (AP) -Liverpool manager Kenny Dalglish wants a determined response from the players he lambasted for their weekend performances when his team takes on Manchester City on Wednesday for a place in the League Cup final.
Dalglish tore into his players after Saturday's woeful 3-1 loss at relegation-threatened Bolton and demanded a much improved display in the semifinals at Anfield.
With the club just one step away from a first final of any kind since the 2007 Champions League, Dalglish said his players were distracted by the match against City. Now they have the chance to show it was worth it.
"I was annoyed and disappointed, more so about the attitude, the commitment and the approach to the game," Dalglish said. "That wasn't us. All season we've been very complimentary about the way the boys have gone about their work but I don't think you could say that on Saturday. Their approach to the game was poor.
"Whether they had their minds on the next two games, I don't know. But every game we play is a very important game."
Liverpool leads City 1-0 from the first leg and the Anfield crowd is set to be in full voice for the visit of the Premier League leaders.
"Now we will get our minds on the Man City game," Dalglish said. "We have to solve our own problems. What do we do to put it right? Same as we always do: we work."
City is on a high after a dramatic 3-2 win over Tottenham on Sunday, but manager Roberto Mancini is keen for his players to forget about the Premier League for a couple of days and focus on what would be a second cup final in two seasons.
Although City looks to have nudged Spurs out of the title race, Mancini believes his team can further improve.
"His words in the dressing room were very profound," assistant manager David Platt said. "Regardless of the fact that it is a great victory against someone who is up there as well, he is not happy at the gift of a goal and the lapse in concentration to allow it to go in.
"He has made that clear in no uncertain terms."
In the other semifinal, Crystal Palace leads second-tier rival Cardiff 1-0 ahead of their second-leg match on Tuesday.
Cardiff, which is third in the League Championship and challenging for promotion, got a taste of cup final action when the Welsh side lost 1-0 to Portsmouth in the 2008 FA Cup final.
The players want another.
"All of the lads know how much it would mean and we're going to drive on together to try and reach Wembley," Cardiff captain Mark Hudson told the club's website. "We're fully focused on what we need to do and we're going out there to play with freedom and get the result."
? 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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More newsGiuseppe Cacace / AFP - Getty ImagesReal Madrid probably will abandon its defensive strategy and go on the attack against Barcelona in the second leg of the Copa del Rey quarterfinals on Wednesday.
Stefano Rellandini / ReutersAC Milan's Kevin-Prince Boateng is hurt again, and his girlfriend says it's because they have sex "7-10 times a week." Oh.
Source: http://nbcsports.msnbc.com/id/44031201/ns/sports-soccer/
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ORANGEBURG, S.C. - - Newt Gingrich trundles into the meeting hall - - a former X-rated movie theater - - to rapturous applause.
He is not the best-looking guy in Republican race or the best-funded or the most ideologically pure. But he has found his shtick, and he is shticking to it.
Continue ReadingNewt Gingrich is the angriest man in America.
Mitt Romney will tell you that Barack Obama is a ?nice guy? but that he is ?in over his head.?
Newt Gingrich will tell you Barack Obama is ?the most radical and most incompetent president in our lifetime!?
Obama is more than incompetent, in fact. To Newt, he is a moron. ?It?s one thing to say the White House can?t play chess, it?s another to say it can?t play checkers,? Newt says and pauses like the professional he is for the laugh to build. ?But tic-tac-toe??
But Obama is more than stupid. He is dangerous. This is important to keep in mind.
The Gingrich campaign is based on the notion of perpetual struggle against perpetual peril.
?How many of you believe the left will fight us every step of the way even after we win?? Gingrich asks the crowd.
The next day, Gingrich will win the South Carolina primary. But he already knows that will happen. That is a given. Just like his nomination and election. But even that will not be enough to silence the ?secular socialists? who oppose him from the left.
The ?left? is a broad category to Gingrich. It includes liberals, socialists, anti-religious bigots, i.e. Democrats, most of the media, some misguided Republicans, and, well, anybody who opposes Newt Gingrich.
?We knew there?d be attacks, and the closer we were to winning the more ferocious the attacks would be,? Gingrich says.
John King of CNN, who asked Gingrich in a debate Thursday night whether he had ever asked his second wife for an ?open? marriage, is part of the ferocious attack machine that seeks to thwart Gingrich.
Gingrich has called this ?despicable? and now he calls it ?grotesque.?
?Is the American news media just totally out of touch with reality?? he asks reporters after the rally. ?You want to say: Get a life! There is a consistent pattern year after year that the American people are sick of the behavior of the news media. Sick!?
Anger, umbrage and bitterness are so much a part of Gingrich?s public persona that he likes to attack the very concept of happiness.
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WASHINGTON ? It could be quite a while yet before the Federal Reserve starts raising the interest rates it's kept at record lows for three years.
Maybe not before 2014.
That's the thinking of many analysts as the Fed prepares this week to provide more explicit clues about how long short-term rates will likely stay near zero.
Starting when their policy meeting ends Wednesday, Fed members plan to forecast the direction of those rates four times a year. The clearer guidance will accompany the Fed's usual quarterly predictions of growth, unemployment and inflation.
The new hints about rates are part of a Fed drive to make its communications with the public more transparent. The more immediate goal is to assure consumers and investors that they'll be able to borrow cheaply well into the future.
No announcements are expected Wednesday of any further Fed action to try to lift the economy. Most analysts think Fed members want to put off any new steps, such as more bond purchases, to see if the economy can extend the gains it's made in recent months.
That's true even though this year's new roster of voting members on the Fed's policy panel suggests that fewer voters would likely oppose further steps to boost the economy. Twice last year, Fed action to try to further lower long-term rates drew three dissenting votes out of 10.
Instead, expectations are focused on the likelihood that the Fed's first quarterly forecast of interest rates will signal no rate increase is probable until at least 2014. That would mark a shift. Since August, the Fed has said in policy statements that it planned to keep its benchmark rate at a record low until at least mid-2013, as long as the economy remained weak.
Here's why analysts expect the Fed to signal that most members see no increase before 2014:
On Wednesday, the Fed will use two charts to signify the thinking of each of its 17 policy committee members about rates.
One chart will illustrate how high each committee member thinks the Fed's benchmark rate will be at the end of 2012, 2013 and 2014.
A second chart will show how many members think the first rate increase will occur in each year from 2012 through 2016.
The charts won't identify any member by name.
Because the range of options extends as far as 2016, many analysts think the consensus view within the Fed is to avoid any rate increase before 2014 ? the average of the possible options.
"Just seeing that the choice of a year for the first hike in the Fed funds rate goes all the way out to 2016 makes us think there are at least a few members of the committee who don't want to raise rates until the unemployment rate gets back down to 5 percent or 6 percent," said Chris Rupkey, chief financial economist at Bank of Tokyo-Mitsubishi.
"We guess there will be some hawks looking for a hike in 2013 and some doves thinking more like 2015," Rupkey said. "The weighted average is likely to be 2014."
Hawks on the Fed tend to be concerned that super-low rates will stoke inflation; doves worry more about high unemployment.
Ward McCarthy, chief financial economist at Jeffries & Co. Inc., said he thinks the Fed's guidance will hint that the first rate increase could come in early 2014.
Others, such as economists at RBC Capital Markets, think the forecasts will suggest no change until late 2014.
A further clue to the Fed's plans will come in its economic projections. In its last projections in November, the Fed forecast that the economy would grow between 2.5 percent and 2.9 percent in 2012. That figure exceeds the forecasts of many private economists. Should the Fed reduce its expectations for growth, that could signal that it's prepared to do more for the economy.
The Fed has already taken numerous unorthodox steps to try to strengthen the economy. Since 2008, for example, it's kept its key rate, the federal funds rate, at a record low between zero and 0.25 percent. It's also bought government bonds and mortgage-backed securities to try to cut long-term rates and ease borrowing costs.
The idea behind the Fed's two rounds of bond buying was to drive down rates to embolden consumers and businesses to borrow and spend more. Lower yields on bonds also encourage investors to shift money into stocks, which can boost wealth and spur more spending.
Some Fed officials have resisted further bond buying for fear it would raise the risk of high inflation later. And many doubt it would help much since Treasury yields are already near historic lows. But Bernanke and other members have left the door open to further action if they think the economy needs it.
The path to such a move could be easier because three regional Fed bank presidents who dissented last year from further Fed action are no longer voting members of the committee. They're being replaced by three who are seen as more likely to back additional efforts to aid the economy.
Vincent Reinhart, a former Fed economist who is chief U.S. economist at Morgan Stanley, says he thinks the Fed will launch another round of bond buying in the spring. That's because he thinks the economy will slow in the current January-March quarter compared with the final months of 2011.
Some think the Fed is most likely to buy more mortgage-backed securities. Doing so could help further reduce record-low mortgage rates and help boost home sales. The weak housing market has held back the economy.
Brian Bethune, an economics professor at Dartmouth College, expects another round of bond purchases in the second half of the year. Bethune thinks the Fed will use those purchases to counter the economic drag that could result if government spending cuts start next January. Those cuts are to take effect unless Congress resolves an impasse on extending tax cuts first passed during the Bush administration.
In addition to providing more guidance on rates, the Fed is weighing other changes in its communications. One could be a new statement to clarify its long-term targets for inflation and unemployment.
The Fed's inflation goal is thought to be between 1.7 percent and 2 percent. Its long-run goal for unemployment is believed to be roughly between 5 percent and 6 percent.
Some private economists say the Fed would start a new bond-buying program only after it resolves an internal debate on its communications strategy ? which could happen as soon as this week.
"They want to get the communications changes out there and get them understood before they do anything else," said Alan Levenson, chief economist at investment firm T. Rowe Price.
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KUWAIT CITY (AP) ? Sheik Saud Al Nasser Al Sabah, who served as Kuwait's ambassador to the U.S. during Iraq's 1990 invasion of the oil-rich country and the American-led war to oust Saddam Hussein's forces, has died, a government-backed newspaper reported Sunday. He was 68.
Al-Qabas said the former diplomat died Saturday. It gave no cause of death.
A member of Kuwait's royal family, Sheik Nasser was a leading voice calling for international help during Iraq's occupation. But he was forced to defend his tactics when it was revealed that his then-teenage daughter, Nayirah, told U.S. lawmakers in October 1990 that she had witnessed Iraqi soldiers yank newborn babies from incubators. Several rights groups later questioned the account, which helped galvanize U.S. public opinion in favor of war.
A statement Sunday from former President George H. W. Bush called Sheik Nasser a "trusted partner" during the occupation and the U.S.-led war in 1991 that drove Saddam's military from Kuwait.
"Throughout that defining ordeal, he stood proudly with the United States as our coalition ejected Saddam's forces from Kuwaiti soil and upheld international law," said Bush's statement from Houston. "He was truly a good man, and a joy with whom to work."
Sheik Nasser served as Kuwait's envoy to Washington from 1981 to 1992. He later served in Kuwait's government as information minister and oil minister.
In the past decade, he played an elder statesmen's role with close ties to the White House and U.S. officials.
He also was a strong opponent of anti-Western views by Islamic hard-liners in Kuwait. In 2003, he joined other Kuwaiti leaders in endorsing the U.S. invasion of Iraq and called it the "beginning of the end" for Muslim extremists.
Al-Qabas newspaper said a funeral was scheduled for Sunday.
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GIGLIO, Italy ? Unregistered passengers might have been aboard the stricken cruise liner that capsized off this Tuscan island, a top rescue official said Sunday, raising the possibility that the number of missing might be higher than the 20 previously announced.
Divers, meanwhile, pulled out a woman's body from the capsized Costa Concordia on Sunday, raising to 13 the number of people dead in the Jan. 13 accident.
Civil protection official Francesca Maffini told reporters the victim was wearing a life vest and was found in the rear of a submerged portion of a ship by a team of fire department divers. The unidentified body was being removed from the ship.
Earlier, Italian authorities raised the possibility that the real number of the missing was unknown because some unregistered passengers might have been aboard.
"There could have been X persons who we don't know about who were inside, who were clandestine" passengers aboard the ship, Franco Gabrielli, the national civil protection official in charge of the rescue effort, told reporters at a briefing on the island of Giglio, where the ship, with 4,200 people aboard rammed a reef and sliced open its hull on Jan. 13 before turning over on its side.
Gabrielli said that relatives of a Hungarian woman have told Italian authorities that she had telephoned them from aboard the ship and that they haven't heard from her since the accident. He said it was possible that a woman's body pulled from the wreckage by divers on Saturday might be that of the unregistered passenger.
But in addition to the body recovered on Sunday, the body found on Saturday and those of three men found a few days earlier, have yet to be identified, because the corpses were badly decomposed after so much time in the water.
Gabrielli said they have identified the other eight bodies: four French, an Italian, a Hungarian, a German and a Spanish national.
Until Sunday, authorities had said that 20 people are still missing.
The search had been halted for several hours early Sunday, after instrument readings indicated that the Concordia has shifted a bit on its precarious perch on a seabed just outside Giglio's port. A few meters (yards) away, the sea bottom drops off suddenly, by some 20-30 meters (65-100 feet), and if the Concordia should abruptly roll off its ledge, rescuers could be trapped inside.
When instrument data indicated the vessel had stabilized again, rescuers went back in, but only explored the above-water section and evacuation staging areas where survivors have indicated that people who did not make it into lifeboats during the chaotic evacuation could have remained.
Passengers were dining at a gala supper when the Concordia sailed close to Giglio and struck the reef, which is indicated on maritime and even tourist maps.
There are also fears that the Concordia's double-bottom fuel tanks could rupture in case of sudden shifting, spilling 2,200 metric tons (almost 500,000 million gallons) of heavy fuel into pristine sea around Giglio, which is part of a seven-island archipelago in some of the Mediterranean's most pristine waters and a prized fishing area.
But Gabrielli said pollutants found near the ship have been detergents and other substances, including chlorine, apparently from the wreck of the ship, which carried some 3,200 passengers and a crew of 1,000. Any fuel traces found were "compatible with what you find in a port," he said.
Ferries and cargo ships regularly call at Giglio's port.
Sophisticated oil-removal equipment has been standing by, waiting for the search-and-rescue operations to conclude before workers can start extracting the fuel in the tanks.
The Italian captain, Francesco Schettino, is under house arrest as prosecutors investigate him for suspected manslaughter, causing a shipwreck and abandoning the ship while many were still aboard.
Operator Costa Crociere, a subsidiary of U.S.-based Carnival Cruise Lines, has said that Capt. Schettino had deviated without permission from the vessel's route in an apparent maneuver to sail close to the island and impress passengers.
Schettino, despite audiotapes of his defying Coast Guard orders to scramble back aboard, has denied he abandoned ship while hundreds of passengers were desperately trying to get off the capsizing vessel. He has said he coordinated the rescue from aboard a lifeboat and then from the shore.
___
D'Emilio reported from Rome.
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WASHINGTON ? Some notable moments from Saturday's South Carolina presidential primary:
___
Fixing for a fight:
Former Massachusetts Gov. Mitt Romney told supporters Saturday to get ready for a long battle ahead.
Romney took sharp aim at President Barack Obama, as well as his GOP rivals' criticism of his time at Bain Capital, the private equity firm he founded.
"If Republican leaders want to join this president in demonizing success and disparaging conservative values, then they're not going to be fit to be our nominee," he said.
Romney finished No. 2 behind Gingrich, having placed first in the New Hampshire primary.
___
Haley's short coattails:
South Carolina Gov. Nikki Haley is riding a wave of popularity. But that wasn't enough to help Romney, whom she endorsed in the primary.
Exit polls found two-thirds of Saturday's voters approved the way Haley is handling her job as governor, including nearly three-quarters of tea party supporters. But Romney won over only about 3 in 10 of those who approved of her job performance.
Gingrich, for his part, won support from about 4 in 10 Haley supporters.
__
`Occupy' Santorum:
Even the "Occupy Wall Street" movement had its moment Saturday.
During Rick Santorum's speech, the former Pennsylvania senator pledged to work to help Americans achieve their potential. But one Occupy protester interrupted him with a jeer: "Unless you're gay. Occupy!" Santorum has long been criticized by gay-rights groups for his opposition to same-sex marriage.
Other Occupy protesters tried to draw focus as Santorum shook hands with supporters after his speech. Santorum's aides and volunteers grabbed the protesters and hauled them from the ballroom at the Citadel.
__
Internet devilry:
Some of South Carolina's notorious 11th-hour shenanigans emerged in a race known at times for its nastiness.
On Saturday, fake email reports ? later denounced by Gingrich and his campaign ? spread on the Internet about Gingrich and his ex-wife Marianne.
State Attorney Gen. Alan Wilson ordered a preliminary review of the phony messages to see if any laws had been broken.
__
Late to the party:
Few things could stop Gingrich Saturday night ? except for a traffic accident.
Campaigning up to the very end, Gingrich ran through five campaign stops on primary day. That included his last at a burger restaurant in Laurens, about an hour northwest of Columbia, where his victory celebration was to take place.
But an accident on the highway delayed Gingrich's bus, making him late to greet supporters.
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